Neuro Library

Neuro Library · Research update

Cerebral no-reflow after thrombectomy: beyond reopening the artery

A new international consensus on definition and imaging assessment.

01

What the consensus proposes

No-reflow describes persistent microvascular hypoperfusion despite reopening large arteries. This Delphi consensus favours angiography alongside perfusion imaging, with CBF/CBV preferred for microvascular assessment. Assessment is preferably within six hours, excluding alternative causes. Quantitative thresholds remain unsettled; this is an expert framework requiring validation.

Synthetic DSA illustration: reopened left M1 with distal arterial filling and no depicted peripheral blush. Not a patient image or a validated no-reflow example.
DSA · SyntheticSynthetic DSA illustration: reopened left M1 with distal arterial filling and no depicted peripheral blush. Not a patient image or a validated no-reflow example.

03 · Evidence

Original paper

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Cerebral No-Reflow after Thrombectomy: International Delphi Consensus on Definition and Imaging AssessmentMujanovic A, Rivet S, ter Schiphorst A, et al. · Annals of Neurology · 12 October 2026 · DOI: 10.1002/ana.78387